Serum neurofilament light chain predicts neurodegeneration in early multiple sclerosis

Takeaway

  • In people with early multiple sclerosis (MS), elevated serum neurofilament light chain (sNfL) is associated with ongoing neuroinflammation and is a potential biomarker of future neurodegeneration.

Why this matters ?

  • There is limited data on predictive biomarkers in early MS that correlate with subsequent lesion burden accumulation and brain atrophy over long follow-up periods.

  • sNfL could prove valuable in predicting disease course and monitoring response to treatment in clinical trials.