Measuring axonal excitability in painful and painless polyneuropathy


  • No significant difference between sensory and motor axonal excitabilities of painful versus painless polyneuropathy using threshold tracking technique. Alternative measures may be required to assess the relationship between neuron excitability and neuropathic pain.

Why this matters

  • With a global aging population, a rising incidence of diabetes and improvements in cancer survival, neuropathic pain is forecasted to become more common.

  • A better understanding of pathophysiology and appropriate biomarkers can help optimize clinical management.