Diffusion MRI morphometry aids diagnosis of Moebius syndrome

Takeaway

  • The volume of the pontine tegmentum region of the brain can be used as an imaging marker for people with the rare neurological condition Moebius syndrome (MBS).

Why this matters

    Moebius syndrome is a rare congenital disorder with unclear etiology and pathogenesis. The findings suggest that diffusion tensor imaging (DTI)-driven tensor-based morphometry may be used in other neurological disorders to detect hypoplasia or atrophy of small pathways and/or brainstem nuclei.