Cerebrospinal fluid neurofilament light chain levels are a marker of disease activity in multiple sclerosis

Takeaway

  • White matter multiple sclerosis lesions containing lipid-laden foamy microglia/macrophages have high acute axonal damage which correlates with increased cerebrospinal fluid neurofilament light chain levels.

Why this matters?

  • Although levels of neurofilament light chain have been used as general indicators or predictors of neuronal damage in neurologic disorders, their role in multiple sclerosis requires further clarification.

  • This unique quantitative neuropathologic analysis of a large multiple sclerosis autopsy cohort demonstrates the feasibility of cerebrospinal fluid neurofilament light chain levels as a biomarker to monitor inflammatory demyelinating lesion activity with axonal damage.